Custom Peptides
Cayman Chemical FluorofenIdon 10mg
An active metabolite of ranolazine inhibits increases in T-wave height and the RR interval in a mouse model of isoprenaline-induced myocardial ischemia
Cayman Chemical CHIR99021hydrochlorIde 10mg
Peptide Sequence amino acids 92-105 (AGVNNEKNWEKTLQ) from the human NAD -dependent 15-PGDH To be used in conjunction with Caymans 15-PGDH Polyclonal Antibody (Item No. 160615) to block protein-antibody complex formation during analysis for 15-PGDH.
Cayman Chemical 2 cyclohexylmethylPLMbagI 10mg
An iron uptake inhibitor inhibits iron uptake (IC50 ~12 UM) as well as induces degradation of TfR1 in HeLa cells reduces serum iron levels and transferrin saturation in rats at 0.2 10 and 40 mg/kg suppresses traumatic brain injury-induced lipid peroxidation neuronal apoptosis and the number of cortical iron deposits in rats
Cayman Chemical MalathIon-d10 10mg
A secondary bile acid produced by gut microbiota increases the growth of Caco-2 cells at 10 and 20 UM increases Foxp3 CD4 Treg levels in a co-culture of naïve T cells and dendritic cells
Cayman Chemical CholesTRolPEG 2000BIotIn 10mg
An internal standard for the quantification of hypoxanthine by GC- or LC-MS
Cayman Chemical HomosIldenafIl 10mg
An active metabolite of baloxavir marboxil inhibits influenza virus CEN and CEN/RdRp activities in cell-free assays (IC50s 2.5 and 1.6 nM respectively) reduces viral titers in MDCK cells infected with laboratory clinical or zoonotic strains of influenza A or B (EC50s 0.46-6.5 nM)
Cayman Chemical 2Deoxy3OIsovaleryladeno 600ug
An analytical reference standard categorized as a tryptamine reduces locomotor activity in mice but does not induce the HTR intended for research and forensic applications
Cayman Chemical CRAMP140-173mousetrIf 10mg
An inhibitor of the Plk1 polo-box domain (apparent IC50 4.8 UM) selective for the Plk1 PBD over Plk2 and Plk3 PBDs (IC50s 18.7 and 53.9 UM respectively) induces cell cycle arrest at the G2/M phase apoptosis and mislocalization of Plk1 in HeLa cells at 5 10 and 25 UM reduces cell proliferation in a panel of 10 cancer cell lines (EC50s 15-35 UM) reduces tumor growth and induces intratumor apoptosis in an MDA-MB-231 mouse xenograft model at 40 mg/kg
Cayman Chemical VU0134992hydrochlorIde 10mg
An antiviral agent inhibits lung viral accumulation in a mouse model of H5N1 influenza A infection at 1 mg/kg inhibits platelet aggregation in a rat model of LPS-induced hypercytokinemia at 20 mg/kg
Cayman Chemical 2Bromo4methylpropIophenon 10mg
An iron uptake inhibitor inhibits iron uptake (IC50 ~12 UM) as well as induces degradation of TfR1 in HeLa cells reduces serum iron levels and transferrin saturation in rats at 0.2 10 and 40 mg/kg suppresses traumatic brain injury-induced lipid peroxidation neuronal apoptosis and the number of cortical iron deposits in rats
Cayman Chemical DabcylKSARSCoV2 ReplIcase 10mg
An inverse agonist of a5 subunit-containing GABAA receptors selectively binds to a1- a2- a3- and a5 subunit-containing GABAA receptors (Kis 0.83 0.85 0.77 and 1.4 nM respectively) over those containing a4 and a6 subunits (Kis 395 and 4000 nM respectively) selectively inhibits GABA-induced currents in L-M(TK-) cells expressing a5 subunit-containing GABAA receptors over those containing a1 a2 or a3 subunits reverses LPS-induced decreases in Bdnf expression in the mouse hippocampus at 3 mg/kg reverses LPS-induced memory consolidation deficits in mice at 3 mg/kg enhances the performance of wild-type rats in a delayed matching-to-place water maze at 0.3 1 and 3 mg/kg reduces immobility in the forced swim test
Cayman Chemical ElacestrnthydrochlorIde 10mg
A colorimetric substrate for prolyl endopeptidase enzymatic cleavage releases pNA which can be quantified by colorimetric detection at 405 nM as a measure of prolyl endopeptidase activity
Cayman Chemical SeralutInIb 10mg
An ACC inhibitor (IC50s 3.5 and 4.1 nM for human ACC1 and ACC2 respectively) inhibits production of palmitate and total fatty acid content in A549 cells at 500 nM induces apoptosis and ER stress in A549 cells at 500 nM inhibits fatty acid synthesis and reduces tumor growth in an A549 mouse xenograft model at 25 mg/kg twice per day
Cayman Chemical PfDHODH-IN-1 10mg
An irreversible PDHK inhibitor (IC50s 49 101 and 313 nM for PDHK1 PDHK2 and PDHK3 respectively) selective for PDHK1-3 over PDHK4 (IC50 10 UM) and 322 other kinases at 10 UM but does inhibit FAK in a cell-free assay but not in a cell-based assay increases ROS production and induces apoptosis in cancer cells with a high ECAROCR ratio reduces the level of glycolysis metabolites in NCI H929 multiple myeloma cells at 0.25 UM reduces tumor growth in an A549 mouse xenograft model
Cayman Chemical ImazalIl-d5sulfate 10mg
An internal standard for the quantification of dabigatran by GC- or LC-MS