Custom Peptides
Cayman Chemical IACS-010759 10mg
An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg
Cayman Chemical 1Stearoyl3Oleoylracglyce 10mg
A diacylglycerol; Intermittent fasting decreases skeletal muscle and hepatic levels in NZO mice; concentration decreases from 4.59 to 1.88% during the dry-curing process of Iberian ham
Cayman Chemical PhosphatIdylethnolamInsoy 10mg
A mixture of phosphatidylethanolamines isolated from soy; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules
Cayman Chemical CyclovIrobuxIn D 10mg
An alkaloid with diverse biological activities; ERG channel blocker (IC50 = 19.7 μM using whole-cell patch-clamp electrophysiology in HEK293 cells expressing the human receptor); increases the amount and rate of calcium release from intracellular stores in healthy neonatal rat cardiac myocytes and those isolated from adult rats with heart failure in a concentration-dependent manner; increases expression of Ryr2 and Serca2a and decreases expression of Ncx; reduces mortality and improves cardiac function in a rat model of congestive heart failure; inhibits doxorubicin-induced myocardial apoptosis and mitochondrial cytochrome C release in mice when preadministered at a dose of 1mg/kg per day for four days; induces cellular autophagy and inhibits growth of MCF-7 breast cancer cells and induces mitochondrial apoptosis in MGC803 and MKN26 gastric cancer cells
Cayman Chemical Cardol trIen 10mg
A phenol from cashew nut shell liquid; inhibits mushroom tyrosinase (IC50 = 2.2 µM); kills 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 µM, respectively; has been used as a starting material for the synthesis of bis-benzoxazines
Cayman Chemical 1 2 3TrIpalmItold31 GlcR 10mg
An internal standard for the quantification of 1,2,3-tripalmitoyl glycerol by GC- or LC-MS
Cayman Chemical C18 CeramIded18 118 0 10mg
A bioactive sphingolipid; the primary short-chain ceramide found in brain tissue; synthesis is regulated by Lass1 in mice; positively correlated to body mass index and inversely related to insulin sensitivity; reduces cell growth in UM-SCC-22A squamous cell carcinoma cells; selectively downregulated in 32 squamous cell carcinoma tumor tissues; positively correlated to body mass index and inversely related to insulin sensitivity in type 2 diabetic patients
Cayman Chemical SW203668trIfluoROCTAte sa 10mg
An irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM); selectively cytotoxic to cancer cell lines that express CYP4F11 over those that don't (IC50s = 22-116 and >10,000 nM, respectively); reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and NOD-SCID mouse xenograft models at 20 and 6 mg/kg, respectively
Cayman Chemical D-Mnose-6-PhosphatesodIum 10mg
A phosphorylated aldohexose that can be used to produce glucose, mannitol, or N-glycans; also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to MRH domains on other proteins
Cayman Chemical PeonIdInchlorIde 10mg
An O-methylated anthocyanidin that exhibits chemopreventive as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells
Cayman Chemical Alntus altsma Alnton 10mg
A quassinoid with diverse biological activities; active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively); inhibits radish seed germination by 88% when used at a concentration of 1 mM; inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 cells at 0.1 μM; reduces tumor volume in 22Rv1, LNCaP, and VCaP CRPC mouse xenograft models at 2 mg/kg
Cayman Chemical NBI 35965mesylate 10mg
A selective CRF1 antagonist (Ki = 4 nM); inhibits cAMP accumulation and ACTH production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo
Cayman Chemical DL-erythrothreo SphngnIn 10mg
A mixture of sphinganine (d16:0), L-erythro sphinganine (d16:0), D-threo sphinganine (d16:0), and L-threo sphinganine (d16:0); decreased in rats following long-term, low-dose administration of dimethoate and is used as a biomarker for dimethoate exposure; found in the fermentation broth of Bacterium SRCnm
Cayman Chemical GemIfloxacInmesylate 10mg
A fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 UG/ml, respectively); useful against respiratory tract infections
Cayman Chemical AmIselImodhydrochlorIde 10mg
A prodrug form of amiselimod phosphate; inhibits the development of chronic colitis induced by adoptive transfer of CD4+CD45RBhigh T cells in mice at 0.3 mg/kg per day